Eptinezumab Plus Patient Education Reduces Monthly Migraine Days in Chronic Migraine With Medication Overuse — In adults with chronic migraine complicated by medication-overuse headache, eptinezumab combined with a brief educational intervention reduced monthly migraine days by 6.
Direct Angiography Transfer Raises Haemorrhage Risk With No Functional Benefit in Severe Stroke — In a randomised trial stopped early for safety reasons, bypassing pre-treatment imaging and transferring suspected large vessel occlusion stroke patients directly to the angiography suite was associated with an approximately elevenfold higher risk of symptomatic intracranial haemorrhage compared with the conventional imaging-first pathway (15% vs 0%; adjusted OR 11.
Sitagliptin/Empagliflozin Fixed-Dose Combinations Significantly Reduce HbA1c in Metformin-Treated Korean Adults — Both fixed-dose combinations of sitagliptin and empagliflozin produced statistically significant reductions in HbA1c compared with placebo at 24 weeks — approximately 0.
Vaginal Microbiota Transplant Without Pretreatment Fails to Resolve Dysbiosis in RCT — In a double-blind randomised controlled trial, vaginal microbiota transplantation (VMT) administered without antibiotic pretreatment showed no statistically significant advantage over placebo in resolving vaginal dysbiosis, with the hazard ratio slightly favouring placebo and a wide confidence interval indicating substantial imprecision (HR 0.
Ad5-Vectored COVID-19 Vaccine Shows No Increased HIV Acquisition Risk in Large Phase 3 Trial — In a Phase 3 randomised controlled trial of 43,780 participants, HIV incidence over six months post-vaccination was 0.
Mazdutide 9 mg Produces 12.78% Mean Weight Loss at 24 Weeks in Chinese Adults with Obesity — In a phase 2 randomized controlled trial, Chinese adults with obesity who received once-weekly mazdutide 9 mg lost a mean of 12.
Polymyxin B Haemoadsorption Shows High Probability of Mortality Benefit in Endotoxic Septic Shock — In a phase 3 Bayesian randomised trial, polymyxin B haemoadsorption was associated with lower 28-day mortality compared with standard care alone in patients with endotoxic septic shock (39% vs 45%; posterior probability of benefit 95.
MUSKARDIA Shows Non-Significant Cardiovascular Trend in Stable CAD Patients With Reduced Kidney Function — In patients with stable coronary artery disease and reduced kidney function, Shexiang Baoxin pill (MUSKARDIA) did not significantly reduce major adverse cardiovascular events compared to placebo, showing an imprecise roughly 29% lower relative risk that did not reach statistical significance (HR 0.
Essential Phospholipids Reduce Hepatic Steatosis and Improve Glycaemic Control in MASLD — In a double-blind, placebo-controlled trial, essential phospholipid (EPL) treatment significantly reduced hepatic steatosis measured by Controlled Attenuation Parameter (CAP) score compared with placebo at six months (p = 0.
Sentinel Node Biopsy Linked to Significantly Reduced Melanoma Death Risk — A meta-analysis of 13 studies and more than 40,000 participants found that melanoma patients who underwent sentinel node biopsy had approximately 14% lower risk of dying from melanoma compared with those who did not (HR 0.