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Research Articles

Clinical Trial

Seizure prophylaxis in glioma surgery: a synopsis from the SPRING RCT.

Underpowered SPRING Trial Leaves Levetiracetam Prophylaxis in Glioma Surgery Unresolved — A phase III randomised controlled trial found no evidence of a difference in 12-month seizure risk between prophylactic levetiracetam and no prophylaxis in seizure-naive glioma patients, but the trial enrolled only 94 of its planned 804 participants, rendering any conclusion statistically unreliable.

Mar 15, 2026 · Health Technol Assess · Neurology
84
Clinical Trial

Thromboembolic Events During Perioperative Therapy for Resectable and Borderline Resectable Pancreatic Cancer in the PREOPANC-2 Trial.

VTE Affects 9% of Resectable PDAC Patients on Neoadjuvant Therapy, Reducing Survival — Venous thromboembolism occurred in 28 of 325 patients (9%) with resectable or borderline resectable pancreatic ductal adenocarcinoma undergoing neoadjuvant treatment within one year of randomization, and its occurrence was associated with decreased overall survival.

Mar 13, 2026 · J Clin Oncol · Cardiology
81
Clinical Trial

Safety and immunogenicity of a single dose of Ad26.COV2.S, BNT162b2, or SARS-CoV-2-rS-protein-nanoparticle in previously vaccinated and unvaccinated adults living with and without HIV in South Africa: a phase 2a randomised, observer-blind trial.

BNT162b2 Boost Elicits Strongest Humoral Response in People Living with HIV — Among people living with HIV who received a single booster dose of one of three COVID-19 vaccines, BNT162b2 produced the largest increases in both binding and neutralising antibodies at day 15, with neutralising antibody titres rising approximately tenfold from baseline (geometric mean fold change 10.

Mar 13, 2026 · Lancet HIV · Infectious Diseases
78
Clinical Trial

Quality of Recovery After Laparoscopic Ovarian Cystectomy: A Randomized Controlled Trial Comparing Opioid-Free Multimodal Analgesia Versus Opioid-Based Anesthesia.

Opioid-Free Multimodal Anesthesia Yields Superior Recovery Quality After Laparoscopic Ovarian Cystectomy — In a double-blind randomized controlled trial of 80 patients, opioid-free multimodal anesthesia produced meaningfully higher quality-of-recovery scores at 24 hours compared with conventional opioid-based anesthesia (QoR-15: 192 vs.

Mar 12, 2026 · Clin Ter · Cardiology
77
Randomized Controlled Trial

Effect of Probiotic Supplementation on Reproductive Outcomes of Women With Polycystic Ovary Syndrome Who Are Candidates for Intrauterine Insemination: A Randomized, Double-Blind, Placebo-Controlled Trial.

Probiotic Supplementation Increases Endometrial Thickness in PCOS Women Undergoing IUI — An 8-week probiotic intervention in women with polycystic ovary syndrome (PCOS) undergoing intrauterine insemination (IUI) produced a statistically significant increase in endometrial thickness compared to placebo (β = 0.

Mar 12, 2026 · Endocrinol Diabetes Metab
83
Randomized Controlled Trial

Plasma and urine biomarker algorithm versus systematic biopsy for prostate cancer detection in elderly men: a randomised trial with early termination for futility.

Biomarker Algorithm Misses Clinically Significant Prostate Cancers, Trial Halted Early — A randomised controlled trial in men aged 70 and older found that a plasma and urine biomarker-based triage algorithm detected clinically significant prostate cancers at a substantially lower rate than standard systematic biopsy — 26% versus 40% — a difference large enough to prompt early termination of the trial for futility.

Mar 12, 2026 · Scand J Urol · Oncology
80
Clinical Trial

Neoadjuvant GOLP in Resectable High-Risk Intrahepatic Cholangiocarcinoma.

Neoadjuvant GOLP Regimen More Than Doubles Event-Free Survival in Resectable High-Risk Intrahepatic Cholangiocarcinoma — In a randomised phase 2–3 trial, patients with resectable high-risk intrahepatic cholangiocarcinoma who received neoadjuvant GOLP (gemcitabine-oxaliplatin, lenvatinib, and the PD-1 inhibitor toripalimab) before surgery had a median event-free survival of 18.

Mar 11, 2026 · N Engl J Med · Oncology
76
Clinical Trial

Percutaneous hepatic perfusion combined with ipilimumab and nivolumab for metastatic uveal melanoma (CHOPIN): a single-centre, open-label, randomised, phase 2 trial.

Adding Ipilimumab and Nivolumab to Hepatic Perfusion Triples One-Year PFS in Uveal Melanoma — In a randomised phase 2 trial, combining percutaneous hepatic perfusion with ipilimumab and nivolumab more than tripled one-year progression-free survival compared with perfusion alone — 54.

Mar 11, 2026 · Lancet Oncol · Oncology
68
Randomized Controlled Trial

IMPACT OF QUADRATUS LUMBORUM BLOCK AND EPIDURAL ANALGESIA ON FUNCTIONAL RECOVERY OF THE LIVER AFTER SURGICAL RESECTION FOR COLORECTAL LIVER METASTASES.

Quadratus Lumborum Block Matches Epidural Analgesia for Liver Recovery After Resection — In a prospective randomized trial of 56 patients undergoing liver resection for colorectal metastases, quadratus lumborum (QL) block produced hepatic function, coagulation, and hemodynamic profiles statistically comparable to epidural analgesia (EA), with only minor transient differences that carried no clinical significance.

Mar 11, 2026 · Exp Oncol · Oncology
63