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Research Articles

Randomized Controlled Trial

Effects of acupuncture on improving hormonal and metabolic biochemical characteristics in polycystic ovary syndrome.

Electroacupuncture Improves Hormonal, Metabolic, and Inflammatory Markers in Obesity-Related PCOS — In a randomized controlled trial of 120 women with obesity-related polycystic ovary syndrome, electroacupuncture delivered three times weekly for 16 weeks produced significant reductions in luteinizing hormone, testosterone, fasting insulin, insulin resistance, and multiple inflammatory markers compared with sham acupuncture.

Mar 24, 2026 · Afr J Reprod Health · Metabolism
74
Randomized Controlled Trial

The effect of ginseng extract on fatigue in cancer survivors: a randomized double-blind clinical trial.

Panax Ginseng Significantly Reduces Fatigue in GI Cancer Survivors Over Four Weeks — A randomized, double-blind, placebo-controlled trial found that four weeks of standardized Panax ginseng extract (250 mg/day) produced a clinically meaningful reduction in fatigue scores compared to placebo in gastrointestinal cancer survivors, with an adjusted mean difference of −1.

Mar 23, 2026 · Support Care Cancer · Oncology
81
Clinical Trial

Pyrotinib or placebo in combination with trastuzumab and docetaxel for HER2 positive metastatic breast cancer: long term survival results from randomised phase 3 PHILA trial.

Pyrotinib Added to Trastuzumab and Docetaxel Cuts Death Risk by 36% in HER2-Positive Metastatic Breast Cancer — In a long-term follow-up analysis of the phase 3 PHILA trial, adding pyrotinib to trastuzumab and docetaxel reduced the risk of death by approximately 36% compared with placebo plus the same backbone regimen in patients with previously untreated HER2-positive metastatic breast cancer (HR 0.

Mar 23, 2026 · BMJ · Oncology
96
Randomized Controlled Trial

Unplanned hospital presentations in oncology patients receiving chemotherapy: a secondary analysis of a randomized controlled trial to explore opportunities for improving supportive care.

One in Three Chemotherapy Patients Presents Unplanned, Most Often in Cycle One — Among 346 adult oncology patients followed through their first three chemotherapy cycles, one-third (33%) made at least one unplanned hospital presentation, with 51% of all such presentations occurring during cycle one alone.

Mar 23, 2026 · Support Care Cancer · Oncology
73
Randomized Controlled Trial

Translation approaches to support systemic anti-cancer therapy consent for individuals with limited English proficiency.

Bilingual Consent Forms Improve Cancer Treatment Comprehension in LEP Patients — Among Bengali- or Sylheti-speaking adults with limited English proficiency undergoing a simulated cancer treatment consent consultation, those given a bilingual English-Bengali consent form were nearly four times more likely to understand treatment intent than those given an English-only form (multivariate OR 3.

Mar 23, 2026 · Support Care Cancer · Oncology
68
Clinical Trial

Effects of Exercise on Cognitive Impairment in Patients Receiving Chemotherapy: A Multicenter Phase III Randomized Controlled Trial.

Home-Based Exercise Reduces Cognitive Impairment and Mental Fatigue During Chemotherapy — A multicenter phase III randomized controlled trial found that a structured home-based exercise program significantly reduced cancer-related cognitive impairment and mental fatigue in patients undergoing chemotherapy, with the strongest effects observed in those on 2-week chemotherapy cycles.

Mar 23, 2026 · J Natl Compr Canc Netw · Oncology
71
Randomized Controlled Trial

Mindfulness-Based Stress Reduction Effects on Chemotherapy-Induced Peripheral Neuropathy Among Breast Cancer Survivors.

Mindfulness and Education Programs Both Outperform Usual Care for Chemotherapy-Induced Neuropathy in Breast Cancer Survivors — Both a structured mindfulness program and a breast cancer education support intervention produced larger improvements in chemotherapy-induced peripheral neuropathy symptoms and functional interference than usual care alone, with differences becoming more pronounced at 12 and 26 weeks.

Mar 20, 2026 · Psychooncology · Oncology
61
Clinical Trial

Romiplostim versus Placebo for Chemotherapy-Induced Thrombocytopenia.

Romiplostim Cuts Chemotherapy Dose Modifications More Than Twofold Versus Placebo — In a phase 3 randomized controlled trial, romiplostim allowed 84% of patients with chemotherapy-induced thrombocytopenia to continue chemotherapy without dose modifications, compared with just 36% on placebo — more than twice the rate (risk ratio 2.

Mar 20, 2026 · N Engl J Med · Oncology
87
Randomized Controlled Trial

The effect of hand massage on pain, comfort, and sleep quality in palliative care oncology patients.

Hand Massage Reduces Pain and Improves Sleep in Palliative Oncology Patients — A four-week randomized controlled trial found that twice-daily hand massage sessions significantly reduced pain intensity and improved both subjective and objective sleep quality in palliative care oncology patients compared to a no-intervention control group.

Mar 20, 2026 · Support Care Cancer · Oncology
70
Randomized Controlled Trial

Mediating Effects of Mindfulness Compassion-based Peer Counseling Program for Breast Cancer Survivors: From Mindfulness, Compassion to Others to Depression Reduction.

Serial Mindfulness-to-Compassion Pathway Reduces Depression in Breast Cancer Survivor Peer Counselors — A randomized controlled trial found that breast cancer survivors trained as peer counselors showed meaningful reductions in depressive symptoms through a sequential psychological pathway: increased mindfulness led to greater self-compassion, which fostered compassion toward others, reduced anxiety, and improved quality of life, ultimately lowering depression.

Mar 19, 2026 · Psychosoc Interv · Oncology
66