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Effect of occlusal reduction on post-endodontic pain in teeth with irreversible pulpitis and symptomatic apical periodontitis: A randomized controlled trial.

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Primary Outcome
Post-endodontic pain intensity measured on the Visual Analogue Scale (VAS) at multiple postoperative time points
Key Finding
Occlusal reduction significantly reduced post-endodontic pain scores compared to no reduction at 6h (p=0.021), 12h (p=0.033), and 24h (p=0.015) after the first root canal visit, with no significant differences from 48h onward.
Reported effect: Significant pain reduction in occlusal reduction group at T1 (p=0.021), T2 (p=0.033), T3 (p=0.015); median pain zero in both groups by T4

AI-generated research brief — verify at source

Occlusal Reduction Reduces Post-Endodontic Pain Within First 24 Hours

In a randomized controlled trial of 180 adults undergoing root canal treatment for irreversible pulpitis with symptomatic apical periodontitis, occlusal reduction produced significantly lower post-operative pain scores than no reduction at 6 hours (p = 0.021), 12 hours (p = 0.033), and 24 hours (p = 0.015) after the first treatment visit. Beyond 48 hours, pain scores converged to near-zero in both groups, indicating that the benefit of occlusal reduction is real but temporally limited to the early post-operative window.

What Was Studied

This trial investigated whether reducing the occlusal surface of a tooth prior to root canal treatment could meaningfully diminish post-operative pain in patients presenting with severe dental pain caused by irreversible pulpitis and symptomatic apical periodontitis. Pain intensity was tracked across eight discrete time points spanning both the first and second endodontic visits, using a visual analogue scale (VAS) as the primary outcome measure.

How It Was Studied

This was a two-arm randomized controlled trial enrolling 200 adults between 18 and 44 years of age, all presenting with carious molars diagnosed as irreversible pulpitis and symptomatic apical periodontitis; 180 participants completed assessment. Group A underwent occlusal reduction before endodontic treatment, while Group B proceeded with root canal treatment on intact occlusal surfaces, serving as the active comparator. Treatment was carried out over two visits by two experienced endodontists following standardized root canal protocols. Pain was self-reported on a VAS at baseline and at five time points after the first visit (6h, 12h, 24h, 48h, 72h) and three time points after the second visit (6h, 24h, 48h).

What Was Observed

  • At baseline, both groups reported comparable severe pain, with a median VAS score of 8 (IQR: 3) and no statistically significant difference between groups (p = 0.900), confirming balanced randomization before any intervention.
  • Occlusal reduction produced statistically significant pain relief during the first 24 hours after the initial endodontic visit: Group A showed lower pain scores than Group B at 6 hours (p = 0.021), 12 hours (p = 0.033), and 24 hours (p = 0.015), indicating a clear early analgesic advantage for the intervention.
  • By 48 hours after the first visit, the median pain score had fallen to zero in both groups and remained negligible through all subsequent follow-up assessments, meaning no significant intergroup differences were detected from T4 through T8 (p > 0.05).
  • The convergence of pain to near-zero in both groups by 48 hours suggests that root canal treatment itself is highly effective at resolving pain, and that occlusal reduction provides supplementary relief specifically during the acute early post-operative phase.

Why This Matters

Patients presenting with irreversible pulpitis and symptomatic apical periodontitis typically experience severe pre-operative pain, and the hours immediately following the first root canal visit represent a vulnerable period for post-operative discomfort. This trial demonstrates that a straightforward procedural modification — reducing the occlusal surface — can meaningfully lower pain intensity during that critical early window without apparent detriment across later follow-up. For clinicians managing patients with severe presentation, this finding supports the inclusion of occlusal reduction as part of an evidence-based endodontic pain management strategy for this specific diagnostic category.

How to Read This Result

While this well-designed RCT provides reasonably strong evidence that occlusal reduction offers statistically significant early pain relief, the benefit is confined to the first 24 hours, effect sizes at individual time points are reported only as p-values without accompanying median differences or confidence intervals, and the absence of explicitly stated limitations in the abstract leaves uncertainty about generalizability across different patient populations, tooth types, and clinical settings.

Limitations

The abstract does not explicitly report study limitations.

Standard journal Publication type: Research Article
Source
J Oral Biol Craniofac Res· PMID: 42761583
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