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Research Articles

Research Article

Immediate versus staged complete revascularization using drug-eluting stents in patients with ST-segment elevation myocardial infarction and multivessel coronary artery disease: An updated meta-analysis after the OPTION-STEMI trial.

Immediate and Staged Complete Revascularization Show Equivalent Outcomes in STEMI with Multivessel Disease — Across six randomized controlled trials pooling 2,837 patients, immediate complete revascularization produced virtually identical rates of cardiac death compared with staged revascularization at 12 months, with no clinically meaningful difference between strategies (RR 0.

Apr 10, 2026 · Kardiol Pol · Cardiology
81
Research Article

Immunogenicity and safety of a quadrivalent recombinant human papillomavirus vaccine (type 6/11/16/18) (Hansenula polymorpha): A randomized controlled phase 2 non-inferiority clinical trial.

Quadrivalent HPV Vaccine Produced in Yeast Achieves Over 99% Seroconversion in Females Aged 9–45 — A randomized, double-blind, placebo-controlled Phase II trial found seroconversion rates exceeding 99% for all four HPV types (6, 11, 16, and 18) in seronegative participants following a three-dose regimen of a quadrivalent HPV vaccine manufactured using the Hansenula polymorpha yeast expression system.

Apr 10, 2026 · Vaccine · Immunology
87
Randomized Controlled Trial

Women’s IschemiA TRial to Reduce Events In Non-ObstRuctive CAD (WARRIOR): a randomised controlled trial.

Intensive Medical Treatment Shows No Reduction in MACE Among Women With ANOCA/INOCA — A randomised controlled trial enrolling 2,476 women with suspected angina and no obstructive coronary artery disease found that intensive medical treatment did not significantly reduce the composite of major adverse cardiovascular events compared with usual care over 2.

Apr 9, 2026 · Open Heart · Cardiology
82
Research Article

Deferral of percutaneous coronary intervention in patients undergoing transcatheter aortic valve implantation (PRO-TAVI): an investigator-initiated, multicentre, open-label, non-inferiority, randomised controlled trial.

Deferring PCI Before TAVI Shows Non-Inferiority at One Year in Coronary Artery Disease Patients — In a multicentre randomised controlled trial of 466 patients, deferring percutaneous coronary intervention (PCI) was non-inferior to performing routine PCI before transcatheter aortic valve implantation (TAVI) for a one-year composite of all-cause mortality, myocardial infarction, stroke, and major bleeding (24% vs 26%; HR 0.

Apr 9, 2026 · Lancet · Cardiology
88
Research Article

Primary care Adherence To Heart failure guidelines in post-Discharge, Evaluation & Routine management (PATHFINDER): a randomised controlled trial.

Hospital-Based Multifaceted Intervention More Than Doubles Guideline Adherence in Heart Failure Patients — A randomised controlled trial found that a structured, hospital-initiated intervention more than doubled the proportion of heart failure patients achieving adherence to five guideline-recommended treatments at six months compared to usual care (61.

Apr 8, 2026 · ESC Heart Fail · Cardiology
80
Meta-Analysis

Risk of Dyslipidemia Associated With Oral Janus Kinase Inhibitors: A Systematic Review and Meta-Analysis of Randomized Placebo-Controlled Trials.

All Four Oral JAK Inhibitors Raise LDL Cholesterol Significantly Versus Placebo — A systematic review and meta-analysis of 13 placebo-controlled trials found that all four oral JAK inhibitors examined—baricitinib, upadacitinib, tofacitinib, and decernotinib—produced consistent, statistically significant elevations in LDL cholesterol compared to placebo, with increases ranging from approximately 9 mg/dL for baricitinib to nearly 16 mg/dL for tofacitinib.

Apr 8, 2026 · Int J Dermatol · Immunology
81
Research Article

Efficacy and Safety of Extended-Release Clonidine Hydrochloride for Attention Deficit Hyperactivity Disorder in Chinese Children and Adolescents: A Multicenter, Randomized, Double-Blind, Placebo-Controlled Trial.

Extended-Release Clonidine Reduces ADHD Symptoms in Chinese Children Over Six Weeks — In a placebo-controlled trial of Chinese children and adolescents with ADHD, once-daily extended-release clonidine produced a meaningfully greater reduction in total symptom scores compared with placebo (least squares mean change: −17.

Apr 8, 2026 · J Child Adolesc Psychopharmacol · Pediatrics
86
Randomized Controlled Trial

West Nile Virus-Neutralizing Plasma for West Nile Virus Disease.

WNV-Neutralizing Plasma Misses Primary Endpoint but Signals Functional and Cognitive Benefit — In a small randomized trial of hospitalized patients with West Nile virus disease, treatment with donor-derived neutralizing plasma produced no reduction in the composite outcome of death or functional deterioration at 30 days compared to placebo — identical rates of 50% in both groups (RR 0.

Apr 7, 2026 · NEJM Evid · Immunology
81
Clinical Trial

Medial retropharyngeal nodal region sparing radiotherapy in nasopharyngeal carcinoma: five year analysis of open label, non-inferiority, multicentre, randomised phase 3 trial.

MRLN-Sparing Radiotherapy Preserves Survival and Reduces Dysphagia in Nasopharyngeal Carcinoma — At five years of follow-up, medial retropharyngeal lymph node (MRLN) sparing radiotherapy achieved non-inferior local relapse-free survival compared with standard radiotherapy (89.

Apr 7, 2026 · BMJ · Oncology
85