ML-Driven PSA Screening Recommendations Reduce Decisional Conflict in Older Men — Men who received personalized machine learning–generated PSA screening recommendations reported meaningfully lower decisional conflict than controls, with a mean score difference of -3.
Durvalumab Added to Perioperative Chemotherapy Improves Survival in Muscle-Invasive Bladder Cancer — In cisplatin-eligible adults with muscle-invasive bladder cancer, adding durvalumab to standard gemcitabine-cisplatin chemotherapy as both a neoadjuvant and adjuvant treatment reduced the risk of disease progression or death by approximately 32% compared with chemotherapy alone (EFS HR 0.
Relacorilant Plus Nab-Paclitaxel Significantly Extends Overall Survival in Platinum-Resistant Ovarian Cancer — Adding relacorilant to nab-paclitaxel reduced the risk of death by approximately 35% compared with nab-paclitaxel alone in patients with platinum-resistant ovarian cancer, extending median overall survival by 4.
Biological DMARDs Offer Modest Pain Gains Over Conventional Therapy in Early RA — At 48 weeks, all four treatment arms in the NORD-STAR trial produced large, clinically meaningful improvements in patient-reported outcomes, with certolizumab pegol and abatacept yielding pain relief exceeding the minimal clinically important difference in 76% and 79% of patients respectively, compared with 68% in the active conventional treatment group.
Adjunctive Prednisolone Fails to Reduce Coronary-Artery Lesions in Kawasaki Disease — Adding prednisolone to standard treatment for Kawasaki disease did not reduce the incidence of coronary-artery lesions at one month after illness onset compared with standard treatment alone — 16.
Sustained Hypertensive SBP Trajectory Carries Highest Risk of Poor Outcome After ICH — In a pooled analysis of 11,269 patients with acute intracerebral hemorrhage, those who maintained a persistently elevated systolic blood pressure trajectory over the first 24 hours had the greatest odds of death or disability at 90 days, regardless of which blood pressure-lowering strategy was applied.
Alternative Front-of-Package Labels Outperform FDA's Proposed Nutrition Scheme in US Adults — In a nationally representative randomised controlled trial of 13,929 US adults, a multilabel warning scheme highlighting only high-nutrient-content items (Multi-High-In) reduced selection of unhealthy foods by 5.
School-Based Physical Activity Gains in Adolescents Fade After Six Months — A systematic review and meta-analysis of 90 randomised controlled trials found that school-based physical activity interventions produced a modest but statistically significant short-term increase in adolescent activity levels (SMD = 0.
Bayesian Precision Dosing Significantly Improves Vancomycin Target Attainment in Critically Ill Children — In a multicentre randomised controlled trial, model-informed precision dosing (MIPD) of vancomycin achieved the pharmacokinetic/pharmacodynamic target in nearly 72% of critically ill children, compared with 54% under standard therapeutic drug monitoring — an absolute improvement of 18.
Oral Semaglutide Reduces Heart Failure Events in Type 2 Diabetes Patients With Established HF — Among people with type 2 diabetes and a prior history of heart failure, once-daily oral semaglutide reduced the composite heart failure outcome by approximately 22% compared with placebo (HR 0.